Mitochondria between degenerative diseases and cancer

Biomedical sciences

 

Host Department
Department of Biomedical Sciences

 

Webpage
http://doctorate.biomed.unipd.it/

Project documents

 

Research Topic B

Mitochondria between degenerative diseases and cancer

 

Rewiring of metabolism enables cancer cells to cope with energy demand required for growth, migration, invasion, and metastasis. Targeting of mitochondrial derangements is under scrutiny to develop innovative anti-tumor strategies. On the other hand, mitochondrial dysfunction has a central role of in neurodegeneration due to alterations in neuronal metabolism and ion homeostasis. Moreover, mitochondrial metabolism modulates astrocyte and microglia reactivity contributing to neuroinflammation.

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