Arterial hypertension and vascular biology
Host Department
Department of Medicine
Hyperaldosteronism and atrial fibrillation
Research Topic A
Abstract of the proposed UNIPhD research project
Primary aldosteronism (PA) is a paradigm of higher aldosterone, low renin hypertension and considered as a benign form of hypertension. Moreover primary aldosteronism has higher prevalence associated with atrial fibrillation (AF) as compared to essential hypertension (EH). Excessive activation of mineralocorticoid receptor via intravascular volume expansion and salt retention may cause cardiovascular damage eventually causing atrial fibrillation and heart failure. Our study aim to find potential pathway followed by aldosterone (ALD) that leads to pathogenesis of atrial fibrillation (AF). Our project is timely and innovative because until now there is no such experimental design being established on animal model. Establishing an animal model and studying atrial fibrillation on it will be a revolutionary point regarding cardiac health in terms of revising screening guidelines for hypertension.
Short bio
Atta Ul Mustafa is an ambitious biomedical researcher who is interested in pursuing his career in cardiovascular sciences. He graduated from Nanjing Medical University, China under Chinese Government Scholarship (CGS) with a Master degree in Physiology from Key Laboratory of Cardiovascular disease and Molecular Intervention with specialization in Ion-Channel Physiology. His research background was closely related to Hypertension where he published his scientific work about how Cav1.2 calcium channels activity in arterial membranes caused vasoconstriction ultimately leading to hypertension. He received his bachelor’s degree in Doctor of Physical Therapy (DPT) from Government College University Faisalabad, Pakistan.
