Clinical and experimental oncology and immunology
Host Department
Department of Surgery, Oncology and Gastroenterology
Genetic susceptibility to cancer
Research Topic B
Abstract of the proposed UNIPhD research project
Retrovirus human T-lymphotropic virus type 1 (HTLV-1) causes an aggressive neoplasm of CD4+ T-cells termed adult T-cell leukemia/lymphoma(ATLL), that arises from the yet incompletely understood interplay that leads to T-cell immortalization. To date, there is no vaccine available to protect against HTLV-1 infection. Studies revealed alterations in the expression of many miRNAs in HTLV-1-infected cells that play roles in the viral life cycle, suggesting that miRNAs could be exploited as anti-HTLV-1 drugs. In addition, studies from the UniPD host lab indicated that selective killing of HTLV-1-infected cells can be obtained with ROS. We will examine the possible ability of miRNAs and ROS-inducing drugs to eliminate HTLV-1-infected cells. miRNAs and drugs will be delivered to cells by encapsulating them in particles conjugated with an antibody against CADM1-highly expressed on the surface of HTLV-1-infected cells-.
Short bio
My name is Arezoo Darbandi and I am 29 years old. I am a master’s degree graduate of Hematology and Blood Banking from Tehran, Iran. I also hold a B.Sc. degree in Clinical Laboratory Science. I have so many novel ideas a I believe that studying PhD helps me put them into practice. I always loved to see myself prospering in the field of oncology and now as a PhD candidate of UNIPD I will try to reach my goals one by one in future.
