Effects of exercise and inactivity in controlling the mitochondrial network and neuromuscular junction

Biomedical sciences


Host Department
Department of Biomedical Sciences



Research Topic A

Abstract of the proposed UNIPhD research project


Research of disuse on mitochondria in skeletal muscles has been studied in many scientific works. However, the topic of how disuse alters mitochondria in slow-twitch and fast-twitch muscle fibers remains understudied.
The aim of the study is to investigate the mechanisms of mitochondrial functional impairments induced by disuse in slow-twitch and fast-twitch muscle fibers. We expect that slow-twitch muscle fibers will have more profound changes after disuse (lower respiration rate, mitochondrial density and alteration in expression of genes involved in metabolic turnover).



Short bio

My name is Evgeniia Motanova. I have a bachelor’s degree in cellular biology and histology and a master’s degree in space biomedical sciences.
Both degrees were acquired in Lomonosov Moscow State University. Currently, I am a junior research fellow at the Institute of Biomedical Problems, in Moscow, Russia. Our laboratory specializes in the effects of disuse on muscle physiology, especially mitochondrial functional impairments due to lack of motional activity. The thesis of my master’s diploma is “The influence of three-day “dry” immersion on mitochondrial respiration rate in m. soleus in women”.

Topic assigned to
Evgeniia Motanova


Project documents