Development of gerosuppressants and senolytic compounds for the treatment of aging and aging‐related disorders

Pharmacological Sciences

Host Department
Department of Pharmaceutical and Pharmacological Sciences

Research Topic B

Abstract of the proposed UNIPhD research project

There is a growing interest in the use of bioactive compounds derived from traditional botanical medicines for slowing aging and cellular senescence. The Alimonti laboratory has identified plant extracts that display gerosuppressant activities with the use of a Pten-null cell model that enables rapid detection of putative senolytic compounds. The aims of this project are to identify the biochemical and pharmacological properties of novel plant extracts for their gerosuppressant and senolytic qualities in vitro and in vivo.

Short bio

Miles Sarill is joining the Veneto Institute for Molecular Medicine as part of the UNIPhD Doctoral Program at the University of Padua to study botanical extracts for their gerosuppressant and senolytic pharmacological properties. Sarill received his MSc in Experimental Medicine from McGill University, in Montreal, Canada, where he studied the regulation of lung antioxidant genes in response to environmental toxicants, and his BSc from the University of Massachusetts Amherst in Pathochemistry. Sarill also has industry experience, working as a scientist at the nutraceutical company CV Sciences.